畢業博士班學術論文

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博士班畢業生一覽表

學生姓名 宋青華(直)
目前職稱 美國康內爾大學副教授
修業期間 73.9 – 78.6
指導教授 張仲明
在學時論文發表
1. Sung, C.-H., Hu, C., Hsu, H.-C., Ng, A.-K., Chou, C.-K., Ting, L.-P., Su, T.-S., Han, S.-H. and Chang, C.(1989). Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma. J. Clin. Invest. 83:421-429.

學生姓名 常筱桂 目前職稱 旅美 修業期間 74.9 – 79.1 指導教授 丁令白 在學時論文發表

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1.Chang, H.-K., Wang, B.-Y., Yuh, C.-H., Wei, C.-L. and Ting, L.-P. (1989). A liver-specific nuclear factor interacts with the promoter region of the large surface protein gene of human hepatitis B virus. Mol. Cell. Biol. 9: 5189-5197.
2.Chang, H.-K. and Ting, L.-P. (1989). The surface gene promoter of the human Hepatitis B virus displays a preference for differentiated hepatocytes.Virology. 170:176-183.

3.Ting, L.-P., Jeng, K.-S., Chou, C.-K., Su, T.-S., Hu, C.-P., Wong, F.-H., Chang, H.-K. and Chang, C. (1988). Expression of oncogenes in human hepatoma cell lines. Chinese J. Microbiol. Immunol. 21:141-150.
4.Chang, H.-K., Chou, C.-K., Chang, C., Su, T.-S., Hu, C., Yoshida, M. and Ting, L.-P. (1987). The enhancer sequence of human hepatitis B virus can enhance the activity of its surface gene promoter. Nucleic. Acid Res. 15:2261-2268.

5.Ting, L.-P. and Chang, H.-K. (1987). Characterization of nucleotide sequence of hepatitis B surface gene and enhancer element of HBV. Chinese J. Microbiol. Immunol. 20:224-240.
6.Ting, L.-P., Chang, H.-K. and Chiang, C.-S. (1986) Expression of hepatitis B surface antigen by yeast actin gene promoter. Biochem. Biophy. Res. Commun. 136:1063-1070.

學生姓名 郭育綺
目前職稱 輔仁大學助理教授
修業期間 73.9 – 79.5
指導教授 林清淵
在學時論文發表
1.Kuo, Y.-C., Lin, C.-Y., Cheng, S.-F., Lin, C.-C. and Liu, W.-T. (1986). National killer cell activity. I. normal range of natural killer cell activity in the Chinese population. Chinese J. Micribol. and Immunolo. 19:112-117.
2.Kuo, Y.-C., Lin, C.-Y., Cheng, C.-F., Lin, C.-C. and Liu, W.-T. (1987). Impaired natural killer cell cytotoxicity during recrudescence of recurrent herpes simplex virus type 2 infection. Cancer Detection and Prevention. 1:51-55.
3.Lin, C.-C., Kuo, Y.-C., Huang, W.-C. and Lin, C.-Y. (1987). The activity of natural killer cell activity in patients of lung cancer. Chest. 92:1022-1024.
4.Lee, B.-H., Kuo, Y.-C., Lin, C.-Y. (1987). Impaired interleukin-2, gamma-interferon production nd natural killer cytotoxicity in active systemic lupus erythematosus patients. Acta aediatrica Sinica. 28:412-419.
5.Lin, C.-Y., Kuo, Y.-C., Lin, C.-C. and Ou, B.-R. (1988). Enhancement of interleukin-2, gamma- interferon production in vitro on cord blood lymphocytes and in vivo on primary cellular immunodeficiency patients with thymic extract (Thumostimulin). J. Cli. Immnol. 8:103-107.
6.Kuo, Y.-C. and Lin, C.-Y. (1990). Recurrent herpes simplex virus type 1 infection precipitated by impaired production of interleukin-2, alpha-interferon, and cell mediated cytotoxicity. J. Med. Virol. 31:183-189.

學生姓名 曾惠中
目前職稱 東吳大學微生物系教授
修業期間 73.6 – 79.6
指導教授 陳文盛
在學時論文發表
1.Tseng, H.-C., Chen, C.-W., Lin, K., Hsu, B.-J., Leu, W.-M., and Lee-Wu, Y.-H. (1991). A cloned ompR-like gene of Streptomyces lividas 66 suppresses defective melCl, a putative copper-transfer gene. Mol. Microbiol. 5:1187-1196.
2.Tseng, H.-C., Lin, C.-K., Hsu, B.-J., Leu, W.-M., Lee-Wu, Y.-H., Chiou, S.-J. Hu, N.-T. and Chen, C.-W. (1990). The melanin operon of Streptomyces antibiotics: expression and use as a marker in Gram-negative bacteria. Gene. 86: 123-128.
3.Tseng, H.-C. and Chen., C.-W. (1991). A cloned ompR-like gene of Streptomyces lividans 66 suppresses defective melCl, a putative copper-transfer gene. Mol. Microbiol. 5:1187-1196.

學生姓名 李蘭瑛
目前職稱 國衛院助理研究員
修業期間 76.9 – 80.5
指導教授 劉世東
在學時論文發表
1.Lee, L.-Y. and Liu, S.-T. (1991). Characterization of the yellow pigment genes of Erwinia herbicola. Mol. Microbiol. 5:217-224 .
2.Liu, S.-T., Lee, L.-Y., Tai, C.-Y., Hung, C.-H., Chang, Y.-S., Wolfram J.-H., Rogers, R., and Glodstein, A.-H. (1992). Cloning of an Erwinia herbiocola gene necessary for gluconic acid production and enhanced mineral phosphate solubilization in Escherichia coli HB101: Nucleotide sequence and probable involvement in biosynthesis of the coenzyme pyrroloquinoline quinone. J. Bacteriology. 174:5814-5819.

學生姓名 鄭金松
目前職稱 中研院研究副技師 修業期間 75.9 – 80.6 指導教授 張仲明 在學時論文發表

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1.Jeng, K.-S., Hu. C., and Chang, C. (1993). Hepatitis B core antigen forms oligomers and complexes with the P gene product in hepatitis B virus core particles. J. Gastroenterol. Hepatol. 8:S114-118. 2.Chiang, P.-W., Jeng, K.-S., Hu, C. and Chang, C. (1992). Characterization of a cis element required for packaging and replication of the human hepatitis B virus. Virology 186:701-711.

3.Ting, L.-P., Jeng, K.-S., Chou, C.-K., Su, T.-S., Hu, C. , Wong, F.-H., Chang, H.-K. and Chang, C. (1988) . Expression of oncogenes in human hepatoma cell lines. Chinese J. Microbiol. Immunol. 21:141-150.
4.Jeng, K.-S., Hu, C. and Chang, C. ( 1991) Differential formation of disulfide linkages in the core antigen of extracellular and intracellular hepatitis B virus core particles. J. Virol.65:3924-3927.

學生姓名 陳善純
目前職稱 國衛院研究員
修業期間 75.9 – 80.5
指導教授 胡承波
在學時論文發表
1.Chen, S.-C., Chou, C.-K., Wong, F.-H., Chang, C., and Hu, C. (1991). Overexpression of epidermal growth factor and insulin-like growth factor-I receptors and autocrine stimulation in human esophageal carcinoma cells. Cancer Res. 51:1898-1903.
2.Wong, F.-H., Hu, C., Chen, S.-C., Yu, Y.-T. and Chang, C. (1992). Absence of genomes of DNA tumor viruses and expression of oncogenes and growth factors in two esophageal carcinoma cell lines of Chinese origin. Chinese J. Microbiol. Immunol. 25:59-68.
3.Liu, Y.-C., Chen, S.-C., Chang, C., Leu, C.-M. and Hu, C. (1996). Platelet-derived growth factor is an autocrine stimulator for the growth and survival of human esophageal carcinoma cell lines. Exp. Cell Res. 228:206-211.

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學生姓名 翁芬華
目前職稱 國立陽明大學生命科學系副教授 修業期間 73.9 – 81.1
指導教授 張仲明
在學時論文發表

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1.Wong, F.-H., Liaw, Y.-F., Hu, C., Chao, Y., Chang, C. and Pao, C.-C. (1993). Analysis of the status of hepatitis B virus DNA in peripheral blood mononuclear cells of chronic hepatitis B patients. J. Gastroenterol. Hepatol. 8: S75-79.
2.Wong, F,-H., Hu, C., Chiu, J.-H., Huang, B.-S., Chang, J.-P., Lin, P.-J., Chien, K.-Y. and Chang , C. (1994). Expression of multiple oncogenes in human esophageal carcinomas. Cancer Invest.12:121-131. 3.Wong, F.-H., Hu, C., Chen, S.-C., Yu, Y.-T. and Chang, C. (1992). Absence of genomes of DNA tumor viruses and expression of oncogenes and growth factors in two esophageal carcinoma cell lines of Chinese origin. Chinese J. Microbiol. Immunol. 25:59-68.

學生姓名 陳淑霞
目前職稱 Mount Sinai 大學助理教授
修業期間 76.9 – 81.6
指導教授 張仲明
在學時論文發表
1.Chen, S.-H., Hu, C., and Chang, C. (1992). Hepatitis B virus replication in well differentiated mouse hepatocyte cell lines immortalized by plasmid DNA. Cancer Res. 52:1329-1335.
2.Chen, S.-H., Hu, C., Lee, C.-K. and Chang, C. (1993). Immune reactions against hepatitis B viral antigens lead to the rejection of hepatocellular carcinoma in BALB/c mice. Cancer Res.53:4648-4651. 3.Chang, P.-C., Hu, C., Chen, S.-H., Wang-Wuu, S. and Chang, C.(1995). Deletion of integrated hepatitis B virus genome and cellular flanking sequences in hepatocellular carcinoma cells in BALB/c mice. Hepatology 21:1504-1509.

學生姓名 喻秋華(直)
目前職稱 國衛院副研究員
修業期間 76.9 – 81.6
指導教授 丁令白
在學時論文發表
1.Yuh, C.-H. and Ting, L.-P. (1993). Differentiated liver cell specificity of the second enhancer of hepatitis B virus. J. Virol. 67:142-149.
2.Yuh, C.-H., Chang, Y.-L. and Ting, L.-P. (1992). Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virus. J. Virol. 66:4073-4084.
3.Yuh, C.-H. and Ting, L.-P. (1991). C/EBP-like proteins binding to the functional box-alpha and box- beta of the second enhancer of hepatitis B virus. Mol. Cell Biol. 11:5044-5052.
4.Yuh, C.-H. and Ting, L.-P. (1990). The genome of hepatitis B virus contains a second enhancer: cooperation of two elements within this enhancer is required for its function. J.Virol. 64:4281-4287. 5.Chang, H.-K., Wang, B.-Y., Yuh, C.-H., Wei, C.-L. and Ting, L.-P. (1989). A liver-specific nuclear factor interacts with the promoter region of the large surface protein gene of human hepatitis B virus. Mol. Cell. Biol. 9: 5189-5197.

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學生姓名 許世宜
目前職稱 高雄醫學大學助理教授
修業期間 77.9 – 82.7
指導教授 羅時成
在學時論文發表
1.Sheu, S,-Y. and Lo, S.-J. (1992). Preferential ribosomal scanning is involved in the differential synthesis of the hepatitis B viral surface antigens from subgenomic transcripts. Virology 188:353-7. 2.Lo, S.-J., Sheu, S.-Y. and Lin, C.-G. (1993). Translational regulation in the expression of hepatitis B viral genes. J. Gastroenterol. hepatol. 8S:45-53.
3.Sheu, S.-Y. and Lo, S.-J. (1994). Biogenesis of the hepatitis B viral middle (M) surface protein in a human hepatoma cell line: demonstration of an alternative secretion pathway. J. Gen. Virol. 75:3031- 3039.
4.Sheu, S.-Y and Lo, S.-J. (1995) Deletion of alteration of hydrophobic animo acids at the first and the third transmembrane domains of hepatitis B surface antigen enhances its production in Escherichia coli. Gene. 160:174-184.
5.Sheu. S.-Y., Chen, K.-L., Lee Wu, Y.-H. and Lo, S.-J. (1996). No intermolecular interaction between the large hepatitis delta antigens is required for the secretion with hepatitis B surface antigen: a model of empty HDV particle. Virology 218:275-278.
6.Chang, H.-H., Sheu, S.-Y. and Lo, S.-J. (1999). Expression of foreign antigens on the surface of Escherichia coli by fusion to an outer member protein TraT. J. Biomed. Sci. 6:64-70.

學生姓名 施勇綸
目前職稱 新光醫院副研究員及台北醫學大學兼任助理教授
修業期間 74.9 – 82.6
指導教授 羅時成
在學時論文發表
1.Shih, Y.-L. Chou. S.-C., Chi, C.-S., Tchen, T.-T. and Lo, S.-J. (1990). Tropic effect of dexamethasone on goldfish melanocytoma cells: induction of calcium-dependent but protein synthesis- independent morphological changes. Life Sci. 47:313-318.

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2.Shih, Y.-L., and Lo, S.-J. (1993). Induction of cell expansion of goldfish melanocytoma cells( GMM- 1) by epinephrine and dexamethasone requires external calcium. Cell Biol. Inter.Rep.17:533-542.

學生姓名 林清宮(直)
目前職稱 嘉南藥理科技大學副教授兼化菻~科主任
修業期間 77.9 – 82.6
指導教授 羅時成
在學時論文發表
1.Lin, C.-G. and Lo, S.-J. (1992). Evidence for involvement of a ribosomal leaky scanning mechanism in the translation of the hepatitis B virus Pol gene from the viral pregenome RNA. Virology 188:342- 352.
2.Lo, S.-J., Sheu, S.-Y. and Lin, C.-G. (1993). Translational regulation in the expression of hepatitis B viral genes. J. Gastroenterol. Hepatol.8:45-53.
3.Lin, C.-G., You, L.-R. and Lo, S.-J. (1993). Expression and stability of hepatitis B pol protein in Escherichia coli. J. Gastroenterol. Hepatol. 8S:54-58.
4.Lin, C.-G., Yang, S.-J., Hwang, W.-L., Su, T.-S. and Lo, S.-J. (1995). Demonstration of the presence of protease-cutting site in the spacer of hepatitis B viral Pol protein. J. Virol. Meth.51:61-74.

學生姓名 徐士蘭
目前職稱 台中榮總醫研部研究員
修業期間 76,9 – 82.1
指導教授 周成功
在學時論文發表
1.Hsu, S.-L., Lin, Y.-F. and Chou, C.-K. (1992). Transcriptional regulation of transferrin and albumin genes by retinoic acid in human hepatoma cell line Hep3B. Biochem. J. 283:611-615.
2.Hsu, S.-L., Lin, Y.-F. and Chou, C.-K. (1993). Retinoic acid biphasically regulates the gene expression of hepatitis B virus surface antigen in human hepatoma Hep3B cells. J.Biol.Chem. 268:23093-23097.

學生姓名 周純芬
目前職稱
修業期間 76.9 – 82.1
指導教授 陳文盛
在學時論文發表
1.Chen, C.-W., Yu, T.-W., Chung, H.-M., and Chou, C.-F. (1992). Discovery and characterization of a new transposible element, Tn4811, in Streptomyxces lividans 66. J. Bacteriology. 174:7762-7769. 2.Chou, C.-F. and Chen, C.-W. (1992). arfJ mutations are highly inducible by ethidium bromide in pro B strains of Streptomyces lividans: Implication of pathway interactions. Biochemical Biophysical

Research Communications.189:1101-1109.

學生姓名 舒佩芸
目前職稱 衛生署疾病管制局副研員
修業期間 76.9 – 82.4
指導教授 胡承波
在學時論文發表
1.Shu, P.-Y., Chang, C., Hwang, L.-H. and Hu, C. (1993) Proliferative and cytotoxic T-cell clones recognize endogenously synthesized HBcAg in an asymtomatic HBsAg carrier. Hepatology 18:275- 283.
2.Shu P.-Y., Lin, M.-Y., Chang, C., Hwang, L.-H., Huang, J.-H., Chang, T.-H. and Hu, C. (1994). Presence of hepatitis B surface antigen(HBsAg)-specific cytotoxic T cells in asymptomatic HBsAg carriers. J. Inf. Dis. 169:633-637.

學生姓名 陳孟良
目前職稱 國衛院研究員
修業期間 75.9 – 82.6
指導教授 張玉生
在學時論文發表
1.Chen, M.-L., Lee, Y-H. and Lo. S.-J. (1988) High-level production of hepatitis B virus (HBV) X protein in Escherichia coli using gene II promoter of M13. Gene 62:315-312.
2.Chang, Y.-S., Chen, M.-L., Su, R.-C., Shu, C.-H. and Liu, S.-T. (1992) Sequence analysis of the BZLF1 gene of Epstein-Barr virus derived from a new variant isolated in Taiwan. Nucleic Acids Res. 20-39.
3.Chen, M.-L., Tsai, C.-N., Huang, C.-L., Liang, C.-H., Shu, Sultzanu, D., Liu, S.-T. and Chang, Y.-S. (1992). Cloning and characterization of the latent membrane protein (LMP) of a specific Epstein-Barr virus variant derived from the nasopharyngeal carcinomas in the Taiwanese population. Oncogne 7:2131-2140.
4.Tyan, Y.-S., Liu, S.-T., Ong, W.-R., Chen, M.-L., Shu, C.-H. and Chang, Y.-S. (1993). Detection of Epstein-Barr virus and human papillomavirus in head and neck tumors in Taiwan. J. Clinical. Microbiology 31:53-56.
5.Chen, M.-L., Wu, R.-C., Liu, S.-T. and Chang, Y.-S. (1995). Characterization of 5′-upstream sequences of the latent membrane protein 1 ( LMPI) gene of an Epstein-Barr virus identified in nasopharyngeal carcinoma tissues. Virus Res. 37:75-84.
6.Chen, M.-L., Hsu, N.-C., Liu, S.-T. and Chang, Y.-S. (1995). Identification of an internal promoter of the latent membrane protein I gene of Epstein-Barr virus. DNA and Cell Biol.14:205-211.
7.Jowett, J.-B., Planclles, V., Poon, B., Shah, N.-P., Chen, M.-L. and Cheng, Y.-S. (1995). The human immunodeficiency virus types 1 vpr gene arrests infected T cells in the G2-M phase of the cell cycle. J.

Virol. 69(10):6304-6312.
8.Akkina, R.-K., Walton, R.-M., Chen, M-L., Li, Q-X. and Cheng, Y.-S. (1996). High-efficiency gene transfer into CD34++ cells with a human immunodeficiency virus type 1-based retroviral vector psudotyped with vesicular stomatitis virus envelope glycoprotein G. J. Virol .70(4):2581-2585.

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學生姓名 陳亞雷
目前職稱 福音技術學院助理教授
修業期間 78.9 – 83.6
指導教授 吳榮燦
在學時論文發表
1.Chen, Y.-L. and Wu, R.-T. (1994). Altered quenine modification of transfer RNA involved in the differentiation of human erythroleukemia K562 cells in the presence of distinct differentiation inducers. Cancer Res. 54:2192-2198.

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學生姓名 蔡亭芬
目前職稱 陽明大學生科系副教授
修業期間 78.9 – 84.2
指導教授 蘇宗笙
在學時論文發表
1.Su, T.-S., Tsai, T.-F., Chi, C.-W., Han, S.-H. and Chou, C.-K. (1990). Elevation of the facilitated glucose transporter messenger RNA in human hepatocellular carcinoma. Hepatology 11, 119-122. 2.Tsai, T.-F., Hsiao, K.-J. and Su, T.-S. (1990). Phenylketonuria mutation in Chinese haplotype 44

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identical with haplotype 2 mutation in Northern-European Caucasians. Hum Genet 84, 409-411. 3.Soong, B.-W., Tsai, T.-F., Su, C.-H., Kao, K.-P., Hsiao, K.-J. and Su, T.-S. (1991). DNA polymorphisms and deletion analysis of the Duchenne/Becker muscular dystrophy gene in Chinese. Am J Med Genet 38, 593-600.

4.Lin, C.-H., Hsiao, K.-J., Tsai, T.-F., Chao, H.-K. and Su, T.-S. (1992). Identification of a missense phenylketonuria mutation at codon 408 in the Chinese. Hum Genet 89, 593-596.
5.Lui, W.-Y., Peng, F.-K., Chang, Y.-F., Chang, T.-J., Tsai, T.-F., Hsu, M.-L., Su, T.-S., Tsay, S.-H., Wu, C.-W., Liu, T.-Y. and Chi, C.-W. (1993). Analysis of glucocorticoid receptors in human hepatocellular carcinoma and HepG2 cells. Hepatology 18, 1167-1174.

6.Tsai, T.-F. and Su, T.-S. (1995). A nuclear post-transcriptional event responsible for overproduction of argininosuccinate synthetase in a canavanine-resistant variant of a human epithelial cell line. Eur J Biochem 229, 233-238.
7.Wang, S.-Y., Chen, L.-Y., Tsai, T.-F., Su, T.-S., Choo, K.-B. and Ho, C.-K. (1996). Constitutive production of colony-stimulating factor(s) by human hepatoma cell lines: possible correlation with cell differentiation. Exp Hematol 24, 437-444.

8.Tsai, T.-F., Wu, M.-J. and Su, T.-S. (1998). Usage of cryptic splice sites in citrullinemia fibroblasts suggests role of polyadenylation in splice-site selection during terminal exon definition. DNA Cell Biol 17, 717-725.
9.Chao, H.-K., Tsai, T.-F., Lin, C.-S. and Su, T.-S. (1999). The study of the p53 codon 249 mutation suggests that activation of the ras gene may not be a major event in aflatoxin B1-related human hepatocarcinogenesis. Mol Carcinogen 26, 69-73.

學生姓名 薛一蘋(直)
目前職稱 中研院分生所助理研究員
修業期間 78.9 – 84.6
指導教授 賴明宗
在學時論文發表
1.Lee, M.-R., Chung, C.-S., Liou, M.-L., Wu, M., Li, W-F, Hiseh, Y.-P. and Lai, M.-Z. (1992) Isolation and characterization of nuclear proteins that bind to TCR Vb promoter decamer motif. J. Immunol. 148:1906-1912.
2.Hsueh, Y.-P., Yang, Y.-F., Liang, H.-E., Han, S.-H. and Lai, M.-Z. (1995). Limited efficacy of T cell receptor-derived peptides to modulate T cell responses. Cell. Immunol. 154: 5675-5683.
3.Hsueh, Y.-P. and Lai, M.-Z. (1995). JNK but not MAP kinase is sensitive to cAMP in T lymphocytes. J. Biol. Chem. 270: 18094-18098.
4.Hsueh, Y.-P. and Lai, M-Z. (1995) Overexpression of ATF-I in activated and in transformed lymphocytes. J. Immunol. 154:5674-5683.
5.Hsueh, Y.-P., Liang, H.-E., Ng, S.-Y. and Lai, M.-Z. (1997) CD28 costimulation activates CREB in T lymphocytes. J. Immunol. 158:85-93.

學生姓名 孫光蕙
目前職稱 國立陽明大學醫技系教授兼所長
修業期間 80.9 – 84.12
指導教授 劉武哲
在學時論文發表
1.Sun, K.-H., Liu, W.-T., Tsai, C.-Y., Liao, T.-S., Lin, W.-M. and Yu, C.-L. (1992) Inhibition of astrocyte proliferation and binding to brain tissue of anticardiolipin antibodies purified from lupus serum. Ann Rheu Dis. 51:707-712.
2.Lieu, C.-W., Liu, W.-T., Sun, K.-H. and Wang, S.-Y. (1993). Some special characteristic of the novel human promonocyte cell line, HL-CZ. J. Biomed. Lab. Sci. 5:196-204.
3.Liu, W.-T., Lee, T.-S., Sun, K.-H., Twu, S.-J., Shi, C.-H. and Wang, G.-R. (1994) The measurement for mRNA level of tumor necrosis factor-脉 from human immunodeficiency virus seropositive individuals. J Biomed Lab Sci. 1994;6:171-176. Sun, K.-H., Liu, W.-T., Tsai, C.-Y., Tang, S.-J., Han, S.-H. and Yu, C.-L. (1995). Anti-dsDNA antibodies cross react with the ribosomal P proteins expressed on the surface of glomerular mesangial cells to exert cytostatic effect. Immunology 85: 262- 269.
4.Sun, K.-H., Liu, W.-T., Tang, S.-J., Tsai, C.-Y., Hsieh, S.-C., Wu, T.-H., Han, S.-H. and Yu, C.-L. (1996) The expression of acidic ribosomal phosphoproteins on the surface membrane of different tissues in autoimmune and normal mice which are the target molecules for anti-dsDNA antibodies. Immunolog 87: 362-371.

學生姓名 陳文明(直)
目前職稱 國立海洋科技大學教授
修業期間 80.9 – 84.6
指導教授 張南驥
在學時論文發表
1.Chen, W.-M., Chang, A.-C., Shie, B.-J., Chang, Y.-H., and Chang, N.-C. (1992). Molecular cloning and characterization of a mouse a2C2 adrenoreceptor subtype gene. Biochem. Biophys. Acta. 1171:219-223.
2.Chang, Y.-H., Chang, N.-C., Chen, W.-M. and Chang, A.-C. (1993). Molecular characterization of a murine homologue of a2C4 adrenoreceptor subtype gene . Biochem. Mol. Biol. Internat. 29:467-474. 3.Chang, N.-C., Jenkins, N.-A., Gilbert, D.-J., Copeland, N.-G., Chang, Y.-H., Chen, W.-M. and Chang, A.-C. (1994). Assignment of two a2 adrenoceptor subtype genes to murine chromosomes. Neurosci. lett. 167:105-108.
4.Chen, W.-M., Chang, A.-C., Wang, C.-M., Lin, C.-C. and Chang, N.-C. (1996). Characterization of the regulatory region of murine a2C2 gene. Neuosci. Lett. 210:33-36.

學生姓名 黃昭菱(直)
目前職稱 長榮大學生物技術學系系主任
修業期間 76.9 – 84.6
指導教授 林清淵
在學時論文發表
1.Huang J.-L. and Lin C.-Y. (1994). A hereditary C3 deficiency due to aberrant splicing of exon 10. Clinical Immunol & Immunopathol 73: 267-273.

學生姓名 林明仙
目前職稱 中研院分生所助理研究員
修業期間 77.9 – 84.1
指導教授 賴明宗
在學時論文發表
1.Lin-Feng, M.-H. and Lai, M.-Z. (1994). A peptide binding weakly to the major histocompatibility molecule augments T cell response. Eur. J. Immunol. 24:355-61.
2.Lin-Feng, M.-H., Shen, Y.-C., Lai, M.-Z. and Liaw, Y.-C. (1996). Selective contact on T cell receptor recognition. Intl. Immunol. 8:45-55.
3.Chang, R.-H., Lin Feng, M.-H., Liu, W.-H., Liu, W.-H. and Lai, M.-Z. (1997) Nitric oxide increased interleulin-4 expression in T lymphocytes. Immunology. 90:364-369.

學生姓名 白其昀
目前職稱 美國內華達大學生物系助理教授
修業期間 79.9 – 84.10
指導教授 葉寧馨
在學時論文發表
1.Pai, C.-Y., Chen, H.-K., Sheu, H.-L. and Yeh, N.-H. (1995). Cell cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis. J. Cell Sci. 108:1911-1920.
2.Pai, C.-Y. and Yeh, N.-H. (1996). Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130. Biochem. Biophy. Res. Commun. 221:581-587.
3.Chen, H.-K., Pai, C.-Y., Huang, J.-Y. and Yeh, N.-H. (1999). Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structure organization. Mol. Cell. Biol. 19:8536-8546.

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學生姓名 陳梨文(直)
目前職稱 元培科學技術學院助理教授
修業期間 78.9 – 85.7
指導教授 劉世東
在學時論文發表
1.Chen, L.-W., Lin, L.-S., Chang, Y.-S. and Liu, S.-T. (1995). Functional analysis of EA-D of Epstein- Barr virus. Virology. 1995; 211:593-7.

學生姓名 黃瑞齡
目前職稱 美濃護校副教授
修業期間 78.9 – 85.6
指導教授 張仲明
在學時論文發表
1.Huang, R.-L., Chen, C.-C., Huang, Y.-L., Hsieh, D.-J., Hu, C., Chen, C.-F. and Chang, C. (1996) Osthole increase glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro. Hepatology. 24:508-515.

學生姓名 李瑞年
目前職稱 高雄醫學大學生物系助理教授
修業期間 78.9 – 85.7
指導教授 劉世東
在學時論文發表
1.Li, S.-N., Chang, Y.-S. and Liu, S.-T.(1996). Effect of a 10 amino acid deletion on the oncogenic activity of latent membrane protein 1 of Epstein-Barr virus. Oncogene. 12:2129-2135.

學生姓名 張懿欣(直)
目前職稱 中山醫學大學醫技系教授
修業期間 79.9 – 85.6
指導教授 黃昭蓮
在學時論文發表
1.Chang, Y.-H., Hwang, J., Shang, H.-F. and Tsai, S.-T. (1996) Characterization of human DNA topoisomerase II as autoantigen recognized by patients with IDDM. Diabetes ( in press).

學生姓名 孫德珊
目前職稱 慈濟大學助理教授

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修業期間 79.9 – 85.6
指導教授 張南驥
在學時論文發表
1.Sun. D.-S., Chang, A.-C., Jenkins, N.-A., Gilbert, D.-J., Copeland, N.-G. and Chang, N.-C. (1996). Identification, molecular characterization and chromosomal localization of the cDNA encoding a novel leucine zipper motif-containing protein. Genomics. 36(1):54-62.

學生姓名 張畫眉(直)
目前職稱 國衛院助理研究員
修業期間 78.9 – 85.10
指導教授 陳文盛
在學時論文發表
1.Chang, H.-M., Chieh, Y.-T., Chen, M.-Y., Bibb, M.-J. and Chen, C.-W. (1996). The cut RS signaltransduction system of Streptomyces lividans represses the biosynthesis of a polyketide antibiotic actinorhodin. Molecular Microbiolgoy. 21:1075-1085.

學生姓名 劉永超
目前職稱 樹德技術學院助理教授
修業期間 79.9 – 85.11
指導教授 胡承波
在學時論文發表
1.Liu, Y.-C., Chen, S.-C., Chang, C., Leu, C.-M. and Hu, C.(1996). Platelet-derived growth factor is an autocrine stimulator for the growth and survival of human esophageal carcinoma cell lines. Exp.Cell Res.

學生姓名 徐欣伶(直) 目前職稱 國衛院研究員 修業期間 78.9 – 85.10 指導教授 葉寧馨 在學時論文發表

1.Hsu, H.-L. and Yeh, N.-H. (1996). Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis. J. Cell Sci. 109:277-288.

學生姓名 張新侯(直) 目前職稱 慈濟大學副教授 修業期間 78.9 – 85.11 指導教授 羅時成 在學時論文發表

1.Chang, H.-H., Hu, S.-T., Huang, T.-F., Chen, S.-H., Lee-Wu, Y.-H. and Lo, S.-J.(1993). Rhodostomin, an RGD-containing peptide expressed from a synthetic gene in Escherichia coli facilitates the attachment of human hepatoma cells. Biochem. Biophys. Res. Commun. 190:242- 249.

2.Chang, H.-H., Chang, C.-P., Chang, J.-C., Dung, S.-Z. and Lo, S.-J. (1997). Application of recombinant rhodostomin in studying cell adhesion. J. Biomed. Sci. 4: 235-243.
3.Chang, H.-H., Tsai, W.-J. and Lo, S.-J. (1997). Glutathione S-transferase-rhodostomin fusion protein inhibits platelet aggregation and induces platelet shape change. Toxicon.35: 195-204. 4.Chang, H.-H. and Lo, S.-J. (1998). Full-spreading platelets induced by recombinant rhodostomin are via binding to integins and correlated with FAK phosphorylation. Toxicon. 36: 1087-1099. 5.Chang, H.-H., Sheu, S.-Y. and Lo, S.-J. (1999). Expression of foreign antigens on the surface of Escherichia coli by fusion to an outer membrane protein TraT. J. Biomed. Sci. 6:64-70.

6.Chang, H.-H., Lin, C.-H. and Lo, S.-J. (1999). Recombinant rhodostomin substrates induce transformation and active calcium oscillation in human platelets. Exp. Cell. Res. 250: 387-400. 7.Chang, H.-H. and Lo, S.-J. (2000). Modification with a phosphorylation tag of PKA in the TraT- based display vector of Escherichia coli. J. Biotech. 78: 115-122.

8.Chang, H.-H., Shih, K.-N. and Lo, S-J. (2000). Receptor-mediated endocytosis as a selection force to enrich bacteria expressin rhodostomin on the surface. J. Biomed. Sci. 7:42-50.

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學生姓名 蔡七女
目前職稱 長庚大學助理教授
修業期間
指導教授 張玉生
在學時論文發表
1.Chang, Y.-S., Lin, Y.-J., Tsai, C.-N., Shu, C.-H., Tsai, M.-S., Choo, K.-B. and Liu, S.-T. (1992). Detection of mutations in the p53 gene in human head and neck carcinomas by single strand conformation polymorphism analysis. Cancer Lett. 67: 167-174.
2.Chen, M.-L., Tsai, C.-N., Huang, C.-R., Liang, C.-L., Shu, C.-H., Sulitzanu, D., Liu, S.-T. and Chang, Y.-S. (1992). Presence of a specific Epstein-Barr virus variant in the nasopharyngeal carcinoma in the Taiwanese population. Oncogene. 7:2131-2140.

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3.Tsai, C.-N., Liu, S.-T. and Chang, Y.-S. (1995). Identification of a novel promoter located within the Bam HI Q region of the Epstein-Barr virus genome for the EBNA 1 gene. DNA. Cell Biol. 14: 767-776.
4.Tsai, C.-N., and Lee, C.-M., Chien, C.-K., Kuo, S.-C. and Chang, Y.-S. (1999). Additive effect of Sp1 and Sp3 in regulation of the ED-L1E promoter of EBV LMP 1 gene in human epithelial cells. Virol. 261:288-294.
5.Chang, Y.-S. (2000). Transcription of Epstein-Barr virus nuclear antigen 1 promoter Qp is repressed by transforming growth factorβ via Smad 4 binding element in human BL cells. Vrol. 277:184-197.

學生姓名 羅瑋瑜
目前職稱 台北醫學大學博士後研究兼任助理教授
修業期間
指導教授 丁令白
在學時論文發表
1.Lo, W.-Y. and Ting, L.-P. (1994). Repression of enhancer II activity by a negative regulatory element in the Hepatitis B virus genome. J. Virol. 68:1758-1764.

學生姓名 高治華
目前職稱 三峽預醫所研究員
修業期間 79.9-86.9
指導教授 丁令白
在學時論文發表
1.Kau, J.-H. and Ting, L-P. (1997). A serine-kinase-containing protein complex interacts with the terminal protein domain of polymerase of Hepatitis B virus. J. Biom. Sci. 4:155-161.
2.Kau, J.-H. and Ting, L.-P. (1998) Phosphorylation of the core protein of hepatitis B virus by a 46-kilodalton serine kinase. J. Virol. 72:3796-3803.

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學生姓名 郭毓良
目前職稱 美國三軍大學博士後研究員

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修業期間 79.9-87.1
指導教授 丁令白
在學時論文發表
1.Kuo, Y.-L. and Ting, L.-P. (1997). Differential regulation of major surface promoter in Hepatitis B virus. DNA. Cell. Biol.16:545-557.

學生姓名 陳浩仁
目前職稱 中山大學生科系副教授
修業期間 80-87
指導教授 鄭淑珍
在學時論文發表
1.Chen, H.-R., Hsu, M.-T. and Cheng, S.-C. (1995). Spheroplast preparation facilitates PCR screening of yeast sequence. BioTechniques 19:744-747.
2.Chen, H.-R., Jan, S.-P., Tsao, T.-Y., Sheu, Y.-J., Banroques, J. and Cheng, S.-C. (1998). Snt309p: a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultancously with or immediately after dissociation of U4 in the same manner as Prp19p. Mol. Cell. Biol. 18:2196-2204.
3.Tsai, W.-Y., Chow, Y.-T., Chen, H.-R., Huang, K.-T., Hong, R.-J., Jan, S.-P., Kuo, N.-Y., Tsao, T.-Y., Chen, C.-H. and Cheng, S.-C. (1999). Cef1p is a component of the Prp19p- associated complex and essential for pre-mRNA splicing. J. Bio. Chem. 274:9455-9462.
4.Chen, H.-R., Tsao, T.-Y., Chen, C.-H., Tsai, W.-Y., Her, L.-S., Hsu., M.-T. and Cheng, S.-C. (1999). Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing. Proc. Natl. Acad. Sci. USA. i96: 5406-5411.
5.Chen, C.-H., Tsai, W.-Y., Chen, H.-R., Wang, C.-H. and Cheng, S.-C. (2001) Identification and characterization of two novel components of the Prp19p-associated complex, Ntc30p and Ntc20p. J. Bio. Chem. 276:488-494.

學生姓名 劉界元
目前職稱 國衛院助理研究員
修業期間 80-87
指導教授 張仲明
在學時論文發表
1.Liou, J.-Y., Jeng, K.-S., Lin, C.-G., Hu, C.-P. and Chang, C. (1998). A novel regulator inhibits HBV gene expression. J. Biomed. Sci. 5:343-354.

學生姓名 吳美誼
目前職稱 美國 Baylor 大學博士後研究員

修業期間 82-87
指導教授 謝世良
在學時論文發表
1.Wu, M.-Y., Hsu,-T.L., Lin, W.-W., Campbell, R.D. and Hsieh, S.-L. (1997). Serine/ Threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-βreceptor in HepG2 cells. J. Biol. Chem. 272: 17154-17159.

2.Wu, M.-Y., Wang, P.-Y., Han, S.-H. and Hsieh, S.-L. (1999). The cytoplasmic domain of the lymphotoxin-βreceptor mediates cell death in Hela cells. J. Biol. Chem. 274: 1868-11873.

學生姓名 杜鴻運
目前職稱 慢性病防治院主任
修業期間 78.9 – 87.7
指導教授 胡承波
在學時論文發表
1.Dou, H.-Y., Wu, J.-C., Peng, W.-L., Chang, C., Chi, W.-K., Chu, Y.-D. and Hu, C. (1998). Analysis of T cell receptor V 刍 gene usage during the course of disease in patients with chronic hapatitis B. J. Biomed. Sci. 5:428-434.

學生姓名 張沛鈞
目前職稱 耶魯大學博士後研究員
修業期間 81-87
指導教授 劉世東
在學時論文發表
1.Chang, P.-C., Chang, Y.-S. and Liu, S.-T. (1998). Characterization of the BcLF1 promoter in Epstein-Barr virus. J. Gen. Virol. 79:2003-2006.
2.Chang, P.-C. and Liu, S.-T. (2001). Function of the intercistronic region of the BRLF1-BZLF1 bicistronic mRNA in translation the Zta protein of the Epstein-Barr virus. J. Virol. 75:1142-1151.

1999 (88 年)

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學生姓名 李婉瑩
目前職稱 國科會生物處副研究員 修業期間 83-90
指導教授 張南驥 在學時論文發表

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學生姓名 許鴻猷
目前職稱 陽明大學基因體中心博士後研究 修業期間 84-91
指導教授 劉世東
在學時論文發表

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學生姓名 洪舜郁
目前職稱 陽明大學藥理所助理教授
修業期間 85-91
指導教授 張南驥
在學時論文發表
1. Hung SI, Chang AC, Kato I and Chang NC. Transient expression of Ym1, a heapin-binding lectin, during developmental hematopoiesis and inflammation. Journal of Leukocyte Biology 2002;72(1):72-82 (SCI).
2. Chang NC, Hung SI, Hwa KY, Kato I, Chen JE, Liu CH and Chang AC. A macrophage protein Ym1 transiently expressed during inflammation is a novel mammalian lectin. Journal of Biological Chemistry 2001;276:17497-17506 (SCI).

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學生姓名 郭瑞琳
目前職稱 美國德州大學博士後研究員
修業期間 87.9-92.9
指導教授 劉武哲
在學時論文發表
1.Kuo RL, Kung SH, Hsu YY, Liu WT. Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death. J Gen Virol. 2002 Jun;83(Pt 6):1367-76.

學生姓名 謝郁華
目前職稱 美國阿拉巴馬大學伯明罕分校博士後研究員
修業期間 88.9-92.9
指導教授 張玉生
在學時論文發表
1.Hsieh YH, Wu CJ, Chow KP, Tsai CL, Chang YS. Electroporation-mediated and EBV LMP1- regulated gene therapy in a syngenic mouse tumor model. Cancer Gene Ther. 2003 Aug;10(8):626-36.

學生姓名 林素珍
目前職稱 美國麻州大學博士後研究員
修業期間 87.9-92.9
指導教授 胡承波
在學時論文發表
1.Lin SJ, Shu PY, Chang C, Ng AK, Hu CP. IL-4 suppresses the expression and the replication of hepatitis B virus in the hepatocellular carcinoma cell line Hep3B. J Immunol. 2003 Nov 1;171(9):4708-16.

學生姓名 詹世鵬
目前職稱 美國耶魯大學博士後研究員
修業期間 87.9-92.9
指導教授 鄭淑珍
在學時論文發表
1.Chan SP, Kao DI, Tsai WY, Cheng SC. The Prp19p-associated complex in spliceosome activation. Science. 2003 Oct 10;302(5643):279-82. Epub 2003 Sep 11.

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學生姓名 蘇文琳
目前職稱 中研院博士後研究員
修業期間 86.9-94.2
指導教授 謝世良
在學時論文發表
Yang CR, Hsieh SL, Teng CM, Ho FM, Su WL, Lin WW. Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action. Cancer Res. 2004 Feb 1;64(3):1122-9.

學生姓名 劉文賢
目前職稱 中研院博士後國防役
修業期間 87.9-94.1
指導教授 賴明宗
在學時論文發表
Liu, W.-H., and Lai, M.-Z. Deltexl regulates T-cell activation by targeted degradation of active MEKK1. Mol. Cell. Biol. 2005. Feb. 25(4):1367-1378.

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學生姓名 鄔康邁
目前職稱 中國北京大學博士後研究員
修業期間 88-95
指導教授 張玉生
在學時論文發表
Role of BRAMI in BMP signaling examined in zebrafish model and cell line

學生姓名 陳昌傑

目前職稱 元智大學助理教授

修業期間 89.9-95.4
指導教授 胡小婷
在學時論文發表
1. Tsay, Y-G., Chen, C.-C., Hu, S.-T.,Identificaton of the-1 translational frameshift using a liquid chromatography-tandem mass spectrometric approa. Anal. Biochem. 339(2005)83-93.

sites

2. Chen, C.-C., and Hu, S.-T. Two frameshift products involved in the transposition of Bacterial Insertion Sequence IS629. J. of Biol. Chem.Vol..281.No.31, pp21617-28, 2006.

學生姓名 劉浩屏 (Hao-Ping Liu)

目前職稱 長庚大學博士後研究 修業期間 89.9~95.9 指導教授 張玉生 在學時論文發表

1. Liu HP, Wu CC, and Chang YS (2006) PRA1 promotes the intracellular trafficking and NF- kapa B signaling of EBV latent membrane protein 1. EMBO J 25(17): 4120-4130.
2. Hsieh YH * , Liu HP * , Lo SJ, and Chang YS (2006) Tumor regression by expression of high physiological levels of EBV latent membrane protein 1. Cancer Biol Ther 5(3): 310-317. ( * co- first author)

3. Chow KP, Lu HC, Chou HF, Liu HP, Hsieh SL, Chang YS, and Choo KB (2002) Induction of chemosensitivity in nasopharyngeal carcinoma cells using a human papillomavirus regulatory sequence and the thymidine kinase gene. J Biomed Sci 9(1): 41-46.

學生姓名:林彥呈
指導教授:丁令白

目前職稱:成功大學博士後研究員
在學時論文發表
Lin YC, Hsu EC, Ting LP., Repression of hepatitis B viral gene expression by transcription factor nuclear factor-kappaB

., Cell Microbiol. 2008 Dec 23 [Epub ahead of print]

學生姓名:雷光昇 指導教授: 胡小婷

目前職稱:陽 明大學 博士後研究員

在學時論文發表

Guang-Sheng Lei, Chii-Jaan Chen, Hanna S.

Yuan, Shao-Hung Wang and Shiau-Ting Hu., Inhibition of IS2 transposition by factor for

inversion stimulation.,

FEMS Microbiology Letters2007;275:98-105

學生姓名:劉浩屏
指導教授:張玉生
目前職稱:長庚大學博士後研究員
在學時論文發表

Liu HP, Wu CC, Chang YS.

, PRA1 promotes the intracellular trafficking and NF-kappaB signaling of EBV latent membrane protein 1.

, EMBO J. 2006 Sep 6; 25(17):4120-30.

學生姓名:林學軒 指導教授: 葉寧馨

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目前職稱:生物技術開發中心副研究員

在學時論文發表

Lin HH, Hsu HL, Yeh NH., Apoptotic cleavage of NuMA at the C-terminal

end is related to nuclear disruption and death

amplification., Journal of Biomedical Science 2007;14:

681-694

學生姓名:劉晏旗

指導教授:鄭淑珍